14 January 2019 - MPPT technology approved as "treatment for wounds" in the EU
The Intended Use of the MPPT technology has today for the EU been approved as ”Treatment for wounds”. This change has been approved by the responsible Notified Body "Eurofins" based a strong clinical data package and a benign safety profile.
7 December, 2018 - Willingsford achieves certification under ISO13485:2016
The Quality Management System implemented by Willingsford Ltd. today received certification under the new and revised ISO-standard for the manufacturing of medical devices: ISO13485:2016.
The certification was performed by the European Group Eurofins.
1 November, 2018 - Press release - Wound infection: Don't kill the bacteria!
A new study published today in the US medical journal WOUNDS has proven that wound infection must be treated by helping the body establish the right bacteria instead of current medical practice, which is to kill them. This is a fundamental shift in how we view infection.
It has for decades been standard practise to use antibiotics and antiseptics to kill bacteria in a wound with the aim to remove an infection. However, in 2016, the FDA concluded that wound dressings containing antibiotics and antiseptics do not remove wound infections and do not improve healing.
The outer surfaces of our body are in constant contact with the environment and it is not possible for the body to keep these sterile. Instead the body actively populates all external surfaces with particular microbes (the microbiome) to ensure there is no “vacant space”. This makes it very difficult for disease-causing microbes to gain a foothold or for one species to suddenly take over control. However, antibiotics and antiseptics indiscriminately kill bacteria and they therefore destroy the balance the body is trying to create. The result is that these treatments do not assist healing, but may even delay healing.
Using a new micropore particle technology (MPPT), it has been possible to reliably remove wound infections and support healing for a wide range of acute and chronic wounds and ulcers. This approach does not kill the bacteria but instead creates conditions that enable the body’s immune system to establish the correct balance of microbes in the wound, and achieving this balance means removing the infection. These findings therefore provide evidence that infections in the wound have to be treated fundamentally differently to infections in internal sterile body regions.
Chief Medical Officer for England, Professor Dame Sally Davies said:
“Antimicrobial Resistance (AMR) is an escalating global threat that puts millions of lives across the world in danger. We cannot rely on the development of new antibiotics alone to mitigate this threat. We need better preventative measures as well as alternative treatments, including innovative ways to use the body’s own immune system and healthy bacteria. I am proud to say the UK are leaders in research into this area.”
Prof. Dame Sally Davies also serves as Executive Board Member of WHO and is Chair of the WHO Strategic and Technical Advisory Group on Anti-Microbial-Resistance.
- In the UK there are annually 2.2 million wounds requiring extended treatment and the direct costs of care to the NHS is £5.3 billion annually (Guest et al. 2015). In community care, Guest et al. (2017) reported that 48% of the wounds are chronic, demonstrating the limitations of current approaches.
- The main reason wounds do not heal is due to infection (Leaper et al. 2015).
- Micropore particle technology (MPPT) consists of small particles filled with pores. They use a combination of capillary flow and evaporation to remove exudate on the wound. This micro-pumping process in parallel removes the toxins and enzymes that bacteria and fungi secrete to inhibit the immune cells and creates holes in the biofilm that bacteria and fungi secrete as a shield against the immune cells. The result is that MPPT disrupts the weaponry of bacteria and fungi, whereby the immune cells regain their ability to selective remove bacteria and fungi to create the balance it wants in the microbiome.
Article Title: Time to Abandon Antimicrobial Approaches in Wound Healing: A Paradigm Shift
Journal: WOUNDS – A Compendium of Clinical Research and Practice, https://www.woundsresearch.com/article/sams-dodd
Publication date: 01 November 2018
1 November, 2018 - Article calling for change in clinical practice published in Wounds
A new study published today in the US medical journal WOUNDS has proven that wound infection must be treated by helping the body's immune system establish the right microbiome instead of current medical practice, which is to eradicate it. This is a fundamental shift in how we view infection.
Title: Time to Abandon Antimicrobial Approaches in Wound Healing: A Paradigm Shift
Authors: Jeanette Sams-Dodd and Frank Sams-Dodd
Journal: WOUNDS – A Compendium of Clinical Research and Practice,
Publication date: 01 November 2018
2-5 July 2018 - MPPT shows effects in pyoderma gangrenosum.
Queen Elizabeth Hospital Birmingham and University Hospital Birmingham, UK this week presented a poster at the the British Dermatology Association meeting in Edinburgh.
The group had evaluated the use of MPPT in three patients with chronic inactive stable PG ulcers. The patients received MPPT for five consecutive days. All demonstrated new granulation tissue consistent with improved healing.
See the poster presented at the British Dermatology Association meeting in Edinburgh, July 2-5, 2018: Pyoderma Gangrenosum Poster.
25 June 2017 - Clinical evaluation of Acapsil by the NHS published in Journal of Wound Care
Clinical audit at Bristol University Hospital, covering 9 acute dehisced surgical wounds and 1 category 4 pressure ulcer (Ryan E (2017) JoWC 26(7)413).
MPPT was able to induce a clean healing wound in 3-5 days. All wounds reached closure. Standard-of-care is 1 week with UrgoClean followed by 2 or more weeks with NPWT to reach the same state of healing as was achieved by 3-5 days with MPPT.
Health economic calculations indicate that MPPT resulted in savings of 67% to reach the healing wound state, when compared to the 1 week with UrgoClean and 2 weeks with NPWT.
25 May 2017 - Press Release: The NHS can save £1.1 billion per year on wound healing – large study documents benefits of novel technology
Southampton, UK, 22 May 2017 - Press Release
This press release contains forward-looking statements about Willingsford Ltd. and the product, Acapsil. Actual results could differ materially from those discussed or implied in this press release due to a number of risks and uncertainties, including the risk that Acapsil and the revenues generated from Acapsil may be affected by competition; unexpected new data; safety and technical issues; clinical trials not being completed in a timely manner, not confirming previous results, or not achieving the intended clinical endpoints; pre-clinical trials not predicting future results; label expansion requests or filings not being submitted in a timely manner; regulatory approval being delayed or not received; or manufacturing and supply issues. The potential for Acapsil may also be affected by government and commercial reimbursement and pricing decisions, the pace of market acceptance, or scientific, regulatory and other issues and risks inherent in the development and commercialisation of pharmaceutical products and medical devices.
25 May 2017 - Acapsil comparative clinical study published in WOUNDS
Bilyayeva O, Neshta VV, Golub A, Sams-Dodd F. (2017) Comparative Clinical Study of the Wound Healing Effects of a Novel Micropore Particle Technology: Effects on Wounds, Venous Leg Ulcers, and Diabetic Foot Ulcers.
Wounds Epub 2017 May 25.
The manuscript of the 266 patient clinical study with Acapsil is published in the American scientific journal WOUNDS: A Compendium of Clinical Research and Practice.
6 April 2017 - Acapsil featured at the annual Tissue Viability Society (TVS) Conference in Edgbaston
30 March 2017 - Willingsford receives Innovate UK grant
Willingsford was today awarded a grant by Innovate UK for its micropore particle technology (MPPT), which has demonstrated clinical efficacy in wound healing.
28 March 2017 - Acapsil presented at the 6'th Annual Infection Prevention and Control meeting in Holyrood.
Acapsil removes infections from wounds without the help of antibiotics and without contributing to the creation of new antibiotic resistance.
This message was highlighted by the Acapsil stand.
7 July 2016 - Acapsil receives CE-certification
Willingsford's lead product, Acapsil receives the CE-mark that allows its commercialisation for use on wounds in humans in the entire European Community.
26 May 2016 - Second publication co-sponsored by Willingsford on the burden of wound care in the UK.
The second article publishing the findings of the study to investigate the burden of wound care in the UK has been published.
The abstract is available here:
Guest, J. F., Ayoub, N., McIlwraith, T., Uchegbu, I., Gerrish, A., Weidlich, D., Vowden, K. and Vowden, P. (2016), Health economic burden that different wound types impose on the UK's National Health Service. Int Wound J. doi:10.1111/iwj.12603.
7 December 2015 - Publication co-sponsored by Willingsford on the burden of wound care in the UK.
Willingsford has co-sponsored a study of the burden of wound care in the UK to promote a better understanding of the extent of this healthcare problem.
The publication is available here:
Guest JF, Ayoub N, McIlwraith T, et al. Health economic burden that wounds impose on the National Health Service in the UK. BMJ Open 2015;5:e009283. doi:10.1136/bmjopen-2015-009283.
9 November 2015 - Willingsford wins place at Innovate UK, the largest innovation show in the UK.
Willingsford wins place at UK’s largest innovation show, Innovate UK, November 9-10, 2015.
Innovate 2015 is the UK’s largest multi-sector innovation event and is organised by Innovate UK and UK Trade and Investment (UKTI). It is set up to create opportunities for export and investment for the UK’s most innovative companies.
24 September 2015 - Presentation: Finding a meaningful target: pros and cons of molecular and functional assays.
Dr. Sams-Dodd from Willingsford give the presentation "Finding a meaningful target: pros and cons of molecular and functional assays" at the pre-meeting workshop "The realities and practicalities of drug discovery and development", 18th World Congress of the International Society on Toxinology. 25-30 September 2015, Oxford, UK.
1 August 2014 - Publication: Effects of SertaSil on wound healing in the rat.
A scientific study comparing the effects of SertaSil on wound healing to a topical antibiotic is published in Journal of Wound Care. See the abstract.
26 June 2014 - Scientific American Worldview 2014 features SertaSil in their new annual issue tracking innovation globally.
Scientific American Worldview 2014 features SertaSil in their new annual issue tracking innovation globally.
See the pdf here: SertaSil 2014 SAWorldView
2 February 2014 - Presentation: Functional Approaches to CNS Drug Discovery and the Potential for Drugs with Multiple Targets as a Mechanism of Action.
Dr. Sams-Dodd from Willingsford gave the plenary lecture "Functional Approaches to CNS Drug Discovery and the Potential for Drugs with Multiple Targets as a Mechanism of Action" at the 8'th Annual Drug Discovery for Neurodegeneration Confrerence in Miami, Florida, USA.
20 January 2014 - Presentation: Target-based or phenotypic drug discovery – which is better or is that the wrong question?
Dr. Sams-Dodd from Willingsford gave an invited presentation "Target-based or phenotypic drug discovery – which is better or is that the wrong question?", which discusses different types of drug discovery approaches at the annual meeting of Society for Laboratory Automation and Screening in San Diego, California, USA.
5 September 2013 - SertaSil- First of its kind. Equestrian Life Magazine, September 2013.
The Equestrian Life Magazine publishes an article on the use of SertaSil in equestian wound care. The article is available as a pdf: Equestian Life Magazine
1 April 2013 - Publication: Is poor research the cause of the declining productivity of the pharmaceutical industry? - An industry in need of a paradigm shift.
Dr. Sams-Dodd from Willingsford publishes a review article in Drug Discovery Today on the problems the pharmaceutical industry has had the pased decade in identifying new effective drugs.
Review article: Sams-Dodd, F. (2013) Is poor research the cause of the declining productivity of the pharmaceutical industry? - An industry in need of a paradigm shift. Drug Discovery Today, vol. 18 (5-6):211-7. http://www.ncbi.nlm.nih.gov/pubmed/23131208
13 December 2012 - Publication: How To Lower Attrition Rates In Labs.
Dr. Sams-Dodd from Wililngsford publishes online article on drug discovery: How To Lower Attrition Rates In Labs. Pharmalive Dec 13, 2012.
4 December 2012 - Publication: R&D Spending & How To Find New Drugs.
Dr. Sams-Dodd from Wililngsford publishes online article on drug discovery: R&D Spending & How To Find New Drugs. Pharmalot Dec. 4, 2012.
12 June 2012 - Willingsford moves to new laboratory facilities in Southampton, UK.
Willingsford has relocated its facilities to the New Forest Enterprise Centre in Southampton, where it currently is setting up laboratory and manufacturing operations.