Now recruiting patients with ulcers for a study supported by NHS England

Contact us if your ulcer is less than 6 weeks old and you live in South-East England

Goal is to determine patient and economic benefits of using Acapsil as first-line treatment at GP-surgeries. Acapsil is already approved and available for sale over-the-counter.

To participate, your venous leg ulcers or diabetic foot ulcers must be less than 6 weeks old.
You must live in Hampshire, East Dorset, West Surrey, Berkshire or the western part of West Sussex.

Goal is to determine patient and economic benefits of using Acapsil as first-line treatment at GP-surgeries. Acapsil is already approved and available for sale over-the-counter.

To participate, your venous leg ulcers or diabetic foot ulcers must be less than 6 weeks old.
You must live in Hampshire, East Dorset, West Surrey, Berkshire or the western part of West Sussex.

60% quicker
than antibiotics

at removing infection

at removing infection

at removing infection

Passive Immunotherapy

Acting via the skin microbiome

Acting via the skin microbiome

Acting via the skin microbiome

Removes pain,
smell and discharge

by efficiently removing the infection

by efficiently removing the infection

by efficiently removing the infection

Less Scarring

"Where I have used Acapsil the scarring is flat, whereas the older scars are hypertrophic." ST

"Where I have used Acapsil the scarring is flat against the surrounding skin, whereas the older scars are bulging / hypertrophic." ST

"Where I have used Acapsil the scarring is flat against the surrounding skin, whereas the older scars are bulging / hypertrophic." ST

"Acapsil changed my life."

"From 4 weeks of absolute hell - to being pain-free, getting a full night's sleep and back to normal at work."

"From 4 weeks of absolute hell, in pain 24 hours a day, struggling at work - to being pain-free, getting a full night's sleep and back to normal at work."

"From 4 weeks of absolute hell, in pain 24 hours a day, struggling at work - to being pain-free, getting a full night's sleep and back to normal at work."

NH ( patient)

NH ( patient)

NH ( patient)

Did you know:
killing the microbes in your wound makes YOU resistant!

MPPT removes infection without killing

MPPT removes infection without killing

MPPT removes infection without killing

69.5% Savings

Cost-effectiveness determined in NHS Clinical Audit

Cost-effectiveness determined in NHS Clinical Audit

Cost-effectiveness determined in NHS Clinical Audit

Hypoallergenic

Only natural ingredients

Only natural ingredients

Only natural ingredients

FDA Executive Review:

Antibiotic and antiseptic dressings do not improve wound infections or wound healing.

Antibiotic and antiseptic dressings do not improve wound infections or wound healing.

Antibiotic and antiseptic dressings do not improve wound infections or wound healing.

US FDA 2016

US FDA 2016

US FDA 2016

In connection with publication on MPPT, the

In connection with publication on MPPT, the

In connection with publication on MPPT, the

Chair of WHO Anti-Microbial-Resistance group said:

“AMR is an escalating global threat. We need alternative treatments, including innovative ways to use the body’s own immune system and healthy bacteria.”

“AMR is an escalating global threat. We need alternative treatments, including innovative ways to use the body’s own immune system and healthy bacteria.”

“AMR is an escalating global threat. We need alternative treatments, including innovative ways to use the body’s own immune system and healthy bacteria.”

“For me, this Acapsil open air method is a no brainer. It is easier, no fuss, and obviously cheaper than these expensive dressings.”

VH (patient)

VH (patient)

VH (patient)

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DFUs, one of the major complications of diabetes

Diabetes mellitus is a chronic disease in which the body’s ability to produce or respond to the hormone, insulin, is impaired. Insulin is a hormone naturally produced by the pancreas. Even though the two states produce a slightly different clinical picture, they both result in elevated levels of glucose / sugar in the blood. Too high blood glucose levels cause damage to many of the body’s systems, in particular the blood vessels and the nerves. The impact is particularly strong in the eyes, kidneys and feet, where it, among others, can lead to, respectively, retinopathy and blindness; nephropathy and kidney failure; and foot ulcerations and amputation.

Treatment goal

Diabetic foot ulcers are categorised depending whether they are neuropathic which means they are caused mainly by neural damage, ischaemic meaning they are mainly due to vascular damage or whether it seems to be a mixture of both, in which case they are categorised neuro-ischemic. The main cause of the ulcer is evaluated as this helps guide the best treatment options, for example offloading. The ulcers are also classified based on the severity, such as depth, level of infection, spread to other structures, such as bone (osteomyelitis) or skin (cellulitis), etc. Whereas these tasks provide important information, the most important undertaking from a patient’s perspective is to act with a sense of urgency and with a view to prevent or delay a potential amputation.  "The primary goal in the treatment of diabetic foot ulcers is to obtain wound closure.” “Prompt and aggressive treatment of diabetic foot ulcers can often prevent exacerbation of the problem and eliminate the potential for amputation. The aim of therapy should be early intervention to allow prompt healing of the lesion and prevent recurrence once it is healed."

How Acapsil can help

Acapsil has shown strong treatment effects and is able to remove an infection in a diabetic foot ulcer 60% quicker and allowed patients to be discharged from hospital 31% quicker, when compared to an antibiotic or an antiseptic. This study was in patients in need of hospitalisation due to their diabetic foot ulcer.

Acapsil removes microbial toxins and enzymes that are weakening the immune cells and preventing them from doing their job properly. This support of the immune system enables the body to repair the damage of the tissue and heal the wound. If the diabetic disease process in the tissue is very advanced, so that the vessels are nearly obstructed and the nerves are close to dying off, even the immune system is no longer able to prevent this from happening and there is no alternative left to amputation. However, it is usually possible to close a diabetic foot ulcer if it is taken seriously immediately when it appears. The optimal approach is, to apply Acapsil immediately upon recognition of the ulcer. Is this not done, however, and the ulcer worsens with the treatment it is receiving, it is still highly recommended to apply Acapsil in order to turn around the process.

The number of applications a diabetic foot ulcer / DFU will need in order to heal, depends fully on the progression of the diabetic disease process and on the age of the ulcer.

♦  If the deep tissue around the ulcer is not very affected and the ulcer is new and relatively small, 1 application will often be enough.

♦  If the ulcer has progressed into the category “difficult-to-heal”, daily application for 3 or 4 consecutive or semi-consecutive days can be necessary, and they may, in difficult cases, need to be followed up with weekly or fortnightly application until full closure of the ulcer is achieved. “Difficult to heal”, in the context, of diabetes means that the ulcer has failed to show good progress towards healing, i.e. 40-50% reduction in size, within 4 weeks.

♦  If the ulcer is older than 6-8 weeks, it is chronic. This means that the number of applications needed may increase. Sometimes, 3 weeks are needed to keep the healing progressing. A positive change will be noticeable from the beginning.

In summary, the actual healing process will be individual to each patient depending on the state of the disease, his/her carefulness with the ulcer for the duration of the healing period and the caution and professionalism of the care provided by all the healthcare professionals participating in the treatment of that particular ulcer.

DFUs, Infection and Acapsil

See case story of 5-year-old diabetic foot ulcer on plantar heel.

In the UK, for first presented diabetic foot ulcers, the outlook for the patient after the first 12 months is 35% healed, 48% unhealed and 17% amputated.

In a clinical study, Acapsil removed the infection from diabetic foot ulcers in less than half the time compared to an antibiotic and an antiseptic. It also cut the number of days the patient needed to remain in hospital by one third.

34% of diabetic foot ulcers managed in the NHS (National Health Service, UK) are treated with systemic antibiotics. Only 16% of these healed. This indicates that antibiotics have a very limited effect on infected diabetic foot ulcers. This use of antibiotics is therefore sub-optimal and it is contributing disproportionately to the development of antibiotic resistance. Acapsil can prevent an infection from developing and can treat a wound infection and it does not contribute to antimicrobial resistance / AMR.

Bone infection / osteomyelitis and skin infection / cellulitis are common complications of diabetic foot ulcers. Both osteomyelitis and cellulitis strongly increase the risk of developing sepsis.

Typical complications associated with diabetes mellitus:

Foot damage / Diabetic foot disease – changes is blood vessels and nerves lead to ulceration and potentially to amputation.

Eye damage / retinopathy – potentially leads to blindness.

Kidney damage / nephropathy – can lead to kidney failure, requiring dialysis or kidney transplant.

Heart disease / cardiovascular disease – including coronary artery disease, heart attack, stroke, atherosclerosis (narrowing of arteries).

Nerve damage / neuropathy - can lead to sensory loss and damage especially in the legs but also hands.

There are two principal forms of diabetes mellitus:

  • Type 1 diabetes (formerly known as insulin-dependent) in which the pancreas fails to produce the insulin which is essential for survival. This form develops most frequently in children and adolescents, but is being increasingly noted later in life.
  • Type 2 diabetes (formerly named non-insulin-dependent) which results from the body's inability to respond properly to the action of insulin produced by the pancreas. Type 2 diabetes is much more common and accounts for around 90% of all diabetes cases worldwide. It occurs most frequently in adults, but is being noted increasingly in adolescents as well.

Recently, a further possible division of diabetes into 5 subgroups has been proposed.

10% of the world’s population has diabetes mellitus. This means that 770 million people around the world suffer from diabetes. Of these, 10% have type 1 and 90% have type 2.

0.6% of the world’s population at any one time has a diabetic foot ulcer. That means that 46.2 million people in the world has a diabetic foot ulcer right now. In North America, this percentage is twice as high.

Every 30 seconds, one lower limb amputation in a diabetes patient occurs around the globe.

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