Now recruiting patients with ulcers for a study supported by NHS England

Contact us if your ulcer is less than 6 weeks old and you live in South-East England

Goal is to determine patient and economic benefits of using Acapsil as first-line treatment at GP-surgeries. Acapsil is already approved and available for sale over-the-counter.

To participate, your venous leg ulcers or diabetic foot ulcers must be less than 6 weeks old.
You must live in Hampshire, East Dorset, West Surrey, Berkshire or the western part of West Sussex.

Goal is to determine patient and economic benefits of using Acapsil as first-line treatment at GP-surgeries. Acapsil is already approved and available for sale over-the-counter.

To participate, your ulcers must be less than 6 weeks old.
You must live in Hampshire, East Dorset, West Surrey, Berkshire or the western part of West Sussex.

Hypoallergenic

Only natural ingredients

Only natural ingredients

Only natural ingredients

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Anti-infective passive immunotherapy for the treatment of wounds and wounds associated with dermatological conditions

What is MPPT?

MPPT is a white odourless powder to be applied directly to the surface of wounds and ulcers that cannot be sutured or where the sutured wound has sprung open.

MPPT is used where normally antibiotics or antiseptics would have been used, e.g. gentamicin, iodine (cadexomer, povidone), silver (Ag), PHMB (polihexidine), octenidine, honey, Manuka honey, chlorhexidine and DACC (Sorbact).

MPPT removes the bacterial and fungal inhibition of the immune system. This returns control of the wound and the wound environment to the immune system which can now efficiently combat the infection and promote healing.

MPPT is the only product on the market that in itself has been approved as a "treatment for wounds".

All other technologies used in the treatment of wounds have been approved as "tools or aids to be used in wound care", e.g. for the absorption of wound exudate and it is then assumed that this will have a positive impact on the wound healing process. The permission to claim MPPT to be a treatment with a therapeutic effect separates it from dressings, creames etc. and places it in a category comparable to pharmaceuticals. This permission was given based on the strong clinical data package and safety profile.

MPPT support the necessary processes to prepare the wound bed for healing

♦ Autolytic debridement.
♦ Infection removal - without the use of antibiotics and antiseptics.
♦ Infiltration removal – i.e. clears the affected deeper tissue in the entire wound region.

These processes lead to faster tissue regeneration - granulation and epithelialisation.
These processes are necessary for wound healing and closure.

MPPT can be used for

♦ Closure of wounds that cannot be sutured
♦ Preparing an area for surgery by removing soft-tissue infection in the area
♦ Removing reminants of a diffuse tissue infection and supporting wound healing following surgery.
♦ Preventing infection in a surgical wound
♦ Inflammatory conditions with disruption of epithelial barriers in the skin

What MPPT does

External facing regions of our body work in synergy with the microbes of the environment to protect our body. On the skin, and hence in wound healing, this means that the ever changing skin-microbiome (the ecosystem of bacteria, fungi, viruses and mites) is necessary and must be conserved and nurtured in the best possible way. If the government of the microbiome is taken over by a specific strain of microbes, i.e. if the balance of the microbiome is disturbed, an infection arises. An infection on the skin or in a wound is removed by restoring the balance between the thousands of different inhabitants of the microbiome so that they all thrive without dominating. Only the immune system knows what the right balance is on that particular spot of skin/wound. Consequently, the immune system must be allowed to govern the microbiome and maintain the balance.

Bacteria and fungi use toxins and enzymes as weaponry against other microbes and the immune system to gain control. As protective armour against the immune system the bacteria and fungi hide inside a biofilm that acts as a shield or fortress that cannot be penetrated by the immune cells (or by antibiotics).

MPPT removes the damaging toxins and enzymes whereby the immune cells regain their strength and abilities; and

MPPT disrupts the shielding biofilm. This allows the newly strengthened immune cells to enter the biofilm and selectively remove unwanted or excess microbes. This restores the balance of the microbiome which again will promote healing.

Therefore, MPPT works by returning the power over the healing process to the individual’s immune system – this makes MPPT an anti-infective passive immunotherapy.

Antimicrobial resistance / AMR

♦ MPPT will remove antibiotic-resistant infections.

♦ MPPT will not contribute to the creation of new resistance.

Storage

MPPT is temperature sensitive and needs to be stored refrigerated.

Classification

MPPT is classified as a medical device and approved for use in humans in the EU.

Doping

WADA, World Anti-Doping Agency have confirmed that normal therapeutic use of MPPT for the purposes of wound healing is not prohibited.

Evidence

Randomised comparative clinical trial with 266 patients

Acapsil was compared to antibiotic and antiseptic. Acapsil reduced time for removing infection and starting healing by 60% and number of hospitalisation days by 31% relative to these two major product groups. These effects were seen for general wounds, diabetic foot ulcers and venous leg ulcers.

Clinical evaluation at Bristol University Hospital

10 patients with dehisced surgical wounds. All wounds proceeded towards healing after 3 to 5 days with Acapsil and all closed. Standard of care would have been 1 week with UrgoClean plus 2 weeks with TNP (pump) to reach a similar stage where the wound could proceed towards healing – assuming no complications.

Clinical evaluation of MPPT in pyoderma gangrenosum

University Hospital Birmingham, UK, evaluated MPPT in three patients with chronic inactive stable PG ulcers.

Community care and out-patients case-reports

Acapsil has been able to initiate the healing of several non-healing wounds and ulcers, which had not responded to a wide range of approaches.

Preclinical study in wound healing model

This in vivo study had the same outcome as the clinical study.

Series of case stories from the veterinary world.

It’s not too much of an exaggeration to say Amicapsil changed my life. From 4 weeks of absolute hell, in pain 24 hours a day, struggling at work and looking at possibly taking time off – to being pain-free, getting a full night’s sleep and back to normal at work.” NH

Read case

Why chose MPPT

Demonstrated therapeutic effect
Removes antibiotic resistant infections
Only natural ingredients
No known side-effects
No known allergic reactions

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