Why is impaired wound healing common to diabetes, spinal cord injury and multiple sclerosis?

A simple scratch on the foot in a person with diabetes or to the skin in a person with spinal cord injury (SCI) or multiple sclerosis (MS) can develop into a large wound that gradually spreads under the skin leading to osteomyelitis (bone infection) and sinus tract formation, i.e. bacteria and fungi boring tunnels into the tissue…

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How antiseptics and disinfectants make you resistant to antibiotics.

It has always been assumed that antimicrobial resistance would only develop in response to the use of antibiotics, but newer data suggest that antiseptics, disinfectants and other antibacterial approaches are even worse at creating resistance. Data namely indicate that these chemicals cause the bacteria to become tolerant or resistant not only to a specific antiseptic or disinfectant,…

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Why may some ulcers need more applications of MPPT than wounds?

Diabetic foot ulcers and venous leg ulcers originate as secondary symptoms of a primary disease process that affects the entire body, i.e. diabetes and cardiovascular disease, respectively. Among the symptoms of both diseases are ulcers, and in particular diabetic foot ulcers and venous leg ulcers. Both types of ulcers are caused by internal disease processes in the…

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What is primary intention, secondary intention and tertiary intention healing?

Healing by first intention or Primary intention healing happens when the wound edges are approximated e.g. by sutures, staples or glue. Healing by second intention or Secondary intention healing takes place when the wound edges cannot be approximated and the wound needs to heal from the bottom. Tertiary intention healing is a combination of both of the…

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What is the difference between a wound and an ulcer?

A wound is caused by an external force whereas an ulcer is caused by an internal problem. That was the short answer. The more extended explanation is the following: In an ulcer, the primary tissue breakdown is internal, i.e. the lesion is caused by an underlying disease or other internal reason. This disturbance of the tissue will…

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What is Biofilm?

Biofilm is a mucous substance that bacteria secrete and in which they embed themselves. Biofilms are part of the bacterial defences against the immune system and constitute a barrier to the body’s immune cells as these encounter considerable difficulties penetrating the biofilm in order to target the bacteria inside. Biofilms are complex structures with well organised own…

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