Amicapsil treatment for dehisced surgical wounds

A surgical wound has typically been closed by approximation of the wound edges by either suturing or other closing methods such as stapling. This is called first intention healing. A wound dehiscence means that the wound breaks in the line of the sutures or other closing method and this is usually caused by an infection.

Sometimes a dehiscence can be re-sutured but if the infection is not eradicated before that, it is most likely to open (dehisce) again. Also, an infection leaves the wound edges weak, and the sutures, or other closing method, will not have a good hold but are likely to “slide”. Usually, there is not enough skin along the edges to try suturing for a third time.

A surgical wound that has dehisced / sprung open is usually left to heal by its own means, filling up with new granulation tissue from the bottom. This is called second intention healing or closure by second intend. This process also requires that the infection is cleared.

Amicapsil swiftly removes the infection without the use of antibiotics or antiseptics and this leads to faster tissue regeneration and healing / granulation and epithelialisation.

Scar formation is closely associated with infection. Therefore, the sooner an infection can be controlled the less scarring will occur.

Septicaemia / septicemia / blood poisoning means that the bacteria or other infecting agent, e.g. virus or fungus, have passed over into the blood stream and are being carried round in the body by the blood. This can cause infection in vital organs leading to organ failure, even multiple organ failure. When this happens the person experiences sepsis or septic shock which has a high probability of being fatal.

People who have just had surgery or who have wounds or injuries as a result of an accident are among those most at risk for septicaemia and sepsis.

In the UK 46,000 people die from sepsis annually. (source NHS) i.e. one person every 12 minutes.

In the US, the annual number of deaths caused by sepsis is 270,000 (source CDC), i.e. one person every 2 minutes.

A wound infection is therefore a serious risk factor and its swift removal is as matter of urgency and priority.

Amicapsil removes wound infections 60% quicker than antibiotics and antiseptics.

In the US alone, at least 2 million people get an antibiotic-resistant antibiotic resistant infection and at least 23,000 people die each year. These numbers are from 2013 (source CDC).

Amicapsil removes antimicrobial resistant wound infections, such as MRSA. Furthermore, Amicapsil will not contribute to antimicrobial resistance / AMR.