Bed rest causes complications such as loss of muscle mass, strength and tone; soft tissue change, osteoporosis (bone demineralisation), degenerative joint disease, increased heart rate, decreased cardiac reserve, decreased venous flow, orthostatic hypotension with dysregulated sense of balance, increased risk of pulmonary infections, mental health problems, progressive increase in insulin resistance (key feature of type 2 diabetes), chronic constipation, increased risk of urinary tract infection, immune suppression, increased risk of pressure ulcer formation.
Treating a wound with Amicapsil does not require bed-rest.