A woman (type 2 diabetic) had broken her leg at the level of the ankle, and a metal plate was fixed on each side of the leg. Both wounds had dehisced and were infected deeper and wider than apparent on the surface. Standard of care treatments had been provided over a two months period to promote closure, but without success. The lower leg and foot were kept immobile via a closed, easy to apply and removeable total contact cast boot.
Amicapsil was applied and covered with Mepitel One and gauze. The patient needed to continue using a closed plastic boot which created an anaerobic environment and impeded evaporation and access of air. After the first application the wound began to clear up, including the deeper infection. Daily application was continued for a total of 4 days, whereafter it was changed to once weekly. The wound dehisced fully until reaching viable tissue and all non-viable tissue along the wound edges disappeared. After a total of 7 applications, the wound was clean and healthily granulating.