Why is impaired wound healing common to diabetes, spinal cord injury and multiple sclerosis?

A simple scratch on the foot in a person with diabetes or to the skin in a person with spinal cord injury (SCI) or multiple sclerosis (MS) can develop into a large wound that gradually spreads under the skin leading to osteomyelitis (bone infection) and sinus tract formation, i.e. bacteria and fungi boring tunnels into the tissue…

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How antiseptics and disinfectants make you resistant to antibiotics.

It has always been assumed that antimicrobial resistance would only develop in response to the use of antibiotics, but newer data suggest that antiseptics, disinfectants and other antibacterial approaches are even worse at creating resistance. Data namely indicate that these chemicals cause the bacteria to become tolerant or resistant not only to a specific antiseptic or disinfectant,…

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Water is preferable for wound cleaning… but – Why can hydrogen peroxide (H2O2) be useful in some cases?

It is to be recognised that some wounds have a contusion zone consisting of tissue balancing on the edge between being viable (being able to live) and unviable and therefore destined to die off sooner or later. It is preferable to get rid of the unviable tissue as early in the wound healing process as possible as…

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Why may some ulcers need more applications of MPPT than wounds?

Diabetic foot ulcers and venous leg ulcers originate as secondary symptoms of a primary disease process that affects the entire body, i.e. diabetes and cardiovascular disease, respectively. Among the symptoms of both diseases are ulcers, and in particular diabetic foot ulcers and venous leg ulcers. Both types of ulcers are caused by internal disease processes in the…

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Does the wound heal quicker if I continue applying MPPT after the infection is gone?

No, MPPT is for use during the inflammatory wound healing phase. Once the wound is clean, free of infection and exhibiting new granulation tissue as buds or healthy-red looking connective tissue and / or epithelial tissue, it has exited the inflammatory phase and entered the proliferative healing phase. In the proliferative phase, the healing usually proceeds unhindered…

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Why should Chlorhexidine not be used before the application of MPPT?

Chlorhexidine binds strongly to the skin and tissues. Chlorhexidine is cytotoxic to fibroblasts which are the creators of the connective tissue essential to wound healing. It is toxic to human tissue cells at the same concentrations it is toxic to bacteria. http://www.ncbi.nlm.nih.gov/pubmed/3238890 Chlorhexidine’s activity lasts at least 48 hours but substantially longer periods (4 weeks) have been…

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How does MPPT break up the biofilm and what does this instigate?

Where MPPT touches the biofilm, the MPPT micro-pumps absorb and suck away the water in the biofilm. This creates holes in the biofilm which allow the immune system access to the bacteria inside. Now the immune system can do its job and clear the infection. MPPT works this way on both new and mature biofilm.

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What is Biofilm?

Biofilm is a mucous substance that bacteria secrete and in which they embed themselves. Biofilms are part of the bacterial defences against the immune system and constitute a barrier to the body’s immune cells as these encounter considerable difficulties penetrating the biofilm in order to target the bacteria inside. Biofilms are complex structures with well organised own…

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How does MPPT work (MoA)?

MPPT works in three steps: Absorption, Pumping by capillary forces and Evaporation. The Exudate is absorbed into the MPPT micropore particles. These are highly porous and the pores (or capillaries) are interconnected. The capillaries work as a battery of small individual pumps that by means of capillary forces suck ( pumps) the exudate to the surface of…

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Can I use antiseptics when preparing the wound?

The use of antiseptics is discouraged when preparing the wound for MPPT application. We strongly advise against the use of antiseptics that are cytotoxic to human cells and that accumulate in the tissue, e.g. Chlorhexidine. About Chlorhexidine If for a specific reason it is necessary to use an antiseptic prior to MPPT, a better option would be…

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